Take the New York State Thruway (I-90) to Exit 50. Take the I-290 toward Niagara Falls. Follow the I-290 until you see signs for the Grand Island bridges and the I-190 North (Grand Island). Go over both bridges, proceed for approximately five miles and then take Exit 24, Witmer Road (Route 31).
At the end of the exit ramp, turn left onto Witmer Road. Continue on Witmer Road until the first traffic light and turn right onto Campus Parkway. Continue on Campus Parkway until you reach Monteagle Trail. Turn left on Monteagle Trail to enter the Niagara University campus.