Faculty

Dr. Christopher Stoj

Assistant Professor of Chemistry
College of Arts & Sciences – Chemistry

Email:  cstoj@niagara.edu
Phone:  (716) 286-8505
Office Location:  DePaul Hall 204A

Bio

Publications

1. Augustine, T. J., Kragh, M. E., Sarangi, R., Fujii, S., Liboiron, B. D., Stoj, C. S., Kosman, D. J., Hodgson, K. O., Hedman, B., and Solomon, E. I.  (2008) Spectroscopic studies of perturbed T1 Cu sites in the multicopper oxidases Saccharomyces cerevisiae Fet3p and Rhus vernicifera Laccase: allosteric coupling between the T1 and trinuclear Cu sites. Biochemistry, (in press)
2. Augustine, T. J., Quintanar, L., Stoj, C. S., Kosman D. J., and Solomon E. I. (2007) Spectroscopic and kinetic studies of perturbed trinuclear copper clusters: The role of protons in reductive cleavage of the O-O bond in the multicopper oxidase Fet3p. Journal of the American Chemical Society, 129(43), 13118-13126.
3. Quintanar, Lilliana; Stoj, Christopher; Taylor, Alexander B.; Hart, P. John.; Kosman, Daniel J.; and Solomon, Edward. I (2007) Shall we dance? How a multicopper oxidase chooses its electron transfer partner. Accounts of Chemical Research, 40(6), 445–452.
4. Stoj, Christopher S.; Augustine, Anthony J.; Solomon, Edward I.; Kosman, Daniel J. (2007) Structure-Function Analysis of the Cuprous Oxidase Activity in Fet3p from Saccharomyces cerevisiae. Journal of Biological Chemistry, 282(11), 7862-7868.
5. Stoj, Christopher S.; Augustine, Anthony J.; Zeigler, Lynn; Solomon, Edward I.; Kosman, Daniel J. (2006) Structural Basis of the Ferrous Iron Specificity of the Yeast Ferroxidase, Fet3p. Biochemistry, 45(42), 12741-12749.
6. Kwok, E. Y.; Stoj, C. S.; Severance, S.; Kosman, D. J. (2006) An engineered bifunctional high affinity iron uptake protein in the yeast plasma membrane. Journal of Inorganic Biochemistry, 100(5-6), 1053-1060.
7. Taylor, Alexander B.; Stoj, Christopher S.; Ziegler, Lynn; Kosman, Daniel J.; Hart, P. John. (2005) The copper-iron connection in biology: Structure of the metallo-oxidase Fet3p. Proceedings of the National Academy of Sciences of the United States of America, 102(43), 15459-15464.
8. Stoj, Christopher S. and Kosman, D. J. (2005) Copper Oxidases, in Encyclopedia of Inorganic Chemistry 2nd Ed., R. B. King, ed, John Wiley, in press.
9. Quintanar, Liliana; Stoj, Christopher; Wang, Tzu-Pin; Kosman, Daniel J.; Solomon, Edward I. (2005) Role of Aspartate 94 in the Decay of the Peroxide Intermediate in the Multicopper Oxidase Fet3p. Biochemistry, 44(16), 6081-6091.
10. Shi, Xiaoli; Stoj, Christopher †; Romeo, Annette; Kosman, Daniel J.; Zhu, Zhiwu. (2003) Fre1p Cu2+ Reduction and Fet3p Cu1+ Oxidation Modulate Copper Toxicity in Saccharomyces cerevisiae. Journal of Biological Chemistry, 278(50), 50309-50315. († Contributed equally to the research described in this paper.)
11. Stoj, Christopher and Kosman, Daniel J. (2003) Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin: implication for function. FEBS Letters, 554(3), 422-426.

Current Research

I am fascinated by the structure and function of proteins involved in the maintenance of metal ion homeostasis in biology, specifically as they relate to various neurodegenerative disease states.

Educational Background

• 2006 Ph.D Biochemistry, University at Buffalo, The State University of New York
• 2000 B.S. Chemistry (ACS) and Biology minor, Plattsburgh State University of New York