Dr. Walter Steiner
Dr. Steiner joined the faculty in 2004. He received his Ph.D. in molecular, cellular, and developmental biology from University of Colorado and his Bachelors degree in Biology from University of California Irvine where he graduated Summa Cum Laude. He currently teaches Cell Biology, Bioanalytical Techniques and laboratory, Senior Seminar, Genomics and Proteomics, and Genetics and laboratory II.
He is presently an associate professor with Niagara University, and previously held a postdoctoral fellowship with the Fred Hutchinson Cancer Research Center, Division of Basic Sciences.
His research interests are aimed primarily at understanding the factors determining the location of recombination hot spots, which to date have remained largely mysterious. The cells of humans and other sexually reproducing organisms contain two copies of each chromosome, one from each parent. These chromosome copies, or homologs, contain similar but not always identical genes. During meiosis (the process of forming gametes), genetic information is exchanged between maternal and paternal homologs through a process called homologous recombination. Homologous recombination is essential for ensuring that each cell receives the correct number of chromosomes it is also a major mechanism of repairing DNA damage. When this process fails, chromosomal rearrangements or other mutations leading to cancer can occur. Research in his lab has revealed that a number of simple nucleotide sequence motifs can create recombination hot spots. They are now characterizing several of those motifs and testing whether they act as binding sites for trans-acting factors. They are also testing whether hot spot motifs discovered in S. pombe are also active in the distantly related budding yeast Saccharomyces cerevisiae. If so, it would suggest the exciting possibility that those motifs are active in many organisms, including humans.
Grants, Honors and Fellowships
- 2007-present National Institutes of Health-AREA grant award.
- 2005-2007 Niagara University Research Council Summer Stipends.
- 2005-2007 Niagara University Research Council Research Support Grants.
- 2004-2007 Leukemia and Lymphoma Society Special Fellowship.
- 1999-2002 National Institutes of Health-National Research Service Award.
- Hirota, K., Steiner, W.W., Shibata, T., and Ohta, K.; 2007.; Chromatin configuration at natural meiotic recombination hot spots in fission yeast.; Eukaryotic Cell 6: 2072-2080.
- Steiner, W.W. and Smith, G.R.; 2005.; Natural Meiotic Recombination Hotspots in the S. pombe Genome Successfully Predicted from the Simple Sequence Motif M26.; Mol. Cell Biol 25: 9054-9062.
- Steiner, W.W. and Smith, G.R.; 2005.; Optimizing the Nucleotide Sequence of a Meiotic Recombination Hotspot in Schizosaccharomyces pombe.; Genetics 169: 1973-1983.;
- Farah, J.A., Cromie, G., Davis, L., Steiner, W.W., and Smith, G.R.; 2005.; Activation of an Alternative, Rec12-Independent Pathway of Meiotic Recombination in the Absence of Rad2 (FEN-1 Homolog).; Genetics 171: 1499-1511.
- Farah, J.A. Cromie, G, Steiner, W.W., and Smith, G.R.; 2005.; A novel recombination pathway initiated by the MRN complex eliminates palindromes during meiosis in Schizosaccharomyces pombe.; Genetics 169: 1261-1274.
- Steiner, W.W., Schreckhise, R.W., and Smith, G.R.; 2002.; Meiotic DNA breaks at the S. pombe recombination hot spot M26.; Mol. Cell 9: 847-855.
- Young, J.A., Schreckhise, R.W., Steiner, W.W., and Smith, G.R.; 2002.; Meiotic recombination remote from prominent DNA breaks sites in S. pombe.; Mol. Cell 9: 253-263.
- Steiner, W.W., Liu, G., Donachie, W.D, and Kuempel, P.L.; 1999.; The cytoplasmic domain of FtsK protein is required for resolution of chromosome dimers.; Mol. Microbiol. 31: 579-583.
- Steiner, W.W. and Kuempel, P.L.; 1998.; Cell division is required for resolution of dimer ;;; chromosomes at the dif locus of Escherichia coli.; Mol. Microbiol. 27: 257-268.
- Steiner, W.W. and Kuempel, P.L.; 1998.; Sister chromatid exchange frequencies in Escherichia coli analyzed by recombination at the dif resolvase site.; J. Bacteriol. 180: 6269-6275.
- Tasset, D.M., Kubik, M.F., and Steiner, W.W.; 1997.; Oligonucleotide inhibitors of human thrombin that bind distinct epitopes.; J. Mol. Biol. 272: 688-698.
My general interest is in homologous recombination, particularly in the factors determining the location of so-called recombination hotspots. Homologous recombination results in the exchange of genetic information between homologous chromosomes during meiosis. Those exchange events can occur at multiple sites along the length of chromosomes, but they occur primarily at so-called recombination hotspots. Research in my lab has shown that specific nucleotide sequences determine the location of some hotspots. We are currently identifying those sequences, which we speculate may be responsible for most, if not all, meiotic recombination hotspots.
B.S. Biology, 1991, University of California, Irvine. Ph.D. Molecular, Cellular, and Developmental Biology, 1998, University of Colorado, Boulder.
Board member for Eastern Colleges Science Conference. Current or former member of the American Society of Microbiology, the Genetics Society of America, the American Association for the Advancement of Science and the Rochester Academy of Sciences. Member of Cub Scouts and the Youngstown Volunteer Fire Department (Membership pending).