Senior Research Assistant
Doctor Leonard graduated with a Bachelors in Arts (Magna Cum Laude) from Lawrence Unversity in 1974. She obtained her Ph.D. in Genetics from Cornell University in 1979. She joined the Niagara Staff in 2000. She currently teaches pharmacology and special topics courses.
Her research interests include The Genetic Basis of Coronary Artery Disease.Scientists already know that coronary artery disease involves genetic or inherited factors. My laboratory is working with physicians at The Heart Center of Niagara and researchers from the University at Buffalo to study these genetic factors with the goal of better identifying who is at risk for coronary artery disease. We are also using cultured human cells to explore the changes that occur during the development of the atherosclerotic plaques that cause coronary artery disease.
Recent Presentations & Publications
- Leonard DA, Merhige ME, Greene RS (2008) Lipid Peroxidation Increases Inflammatory Cytokine Expression in Human Macrophages. Arterioscler Thromb Vasc Biol, 28, e-75.
- Greene CJ, Gombert ME, Lucas CA, Leonard DA, Greene RS (2008) Effect of Gene Polymorphisms in the Renin-Angiotensin System on the Progression of Coronary Artery Disease. New York Undergraduate Research Exposition, Albany, NY
- Greene, M, Leonard, D, Merhige, M. (2007) Differential expression of interleukin-5 receptor A in patients with obstructive coronary artery disease. Eastern Colleges Science Conference, New York, NY
- Dominick V. Rutherford, M.A. Kotarski, M. McCourt, and D.A. Leonard (2007) Effects of amino acid substitutions on CHS protein structure in Gesneriaceae. The Mercury Conference for Computational Chemistry, Hamilton College, Clinton, NY
- Leonard, D.A., Merhige, M.E. and Greene, R.S. (2007) Elevated Expression of the Interleukin-8 Receptors CXCR1 and CXCR2 in Peripheral Blood Cells in Obstructive Coronary Artery Disease. Arterioscler Thromb Vasc Biol, 27, e-70.